Why NEUPRO may be right for you

If you have moderate-to-severe primary RLS and are experiencing uncomfortable sensations anytime you're trying to sleep, relax, or just sit still, NEUPRO® (rotigotine transdermal system) may be right for you. NEUPRO is a medication with the proven potential for RLS symptom relief. It is a patch that delivers the dopamine agonist rotigotine through the skin. With NEUPRO, your RLS symptoms are treated with one patch, once a day.

In a 6-month clinical trial, patients with moderate-to-severe primary RLS taking NEUPRO saw improvement in RLS symptoms, measured by a combined score based on the following 10 items:

  • RLS discomfort in arms and legs
  • Need to move around because of RLS symptoms
  • Relief of RLS discomfort from moving around
  • Sleep disturbance due to RLS symptoms
  • Tiredness or sleepiness during the day due to RLS symptoms
  • Severity of RLS as a whole
  • Frequency of RLS symptoms
  • Severity of RLS symptoms
  • Impact of RLS symptoms on daily activities
  • Severity of mood disturbance due to RLS symptoms

See if you can save on NEUPRO

Eligible patients may pay as low as $10 a month for the next 12 months of NEUPRO*

Check eligibility >


*Eligibility restrictions, terms, and conditions apply.


In fact, nearly 1 out of 4 patients (23%) taking NEUPRO were completely symptom-free at the end of the study (compared to nearly 1 out of 10 patients (9%) who used a placebo patch, without any medicine). In other words, these patients had a score of zero on all 10 items, which means no symptoms.

Nearly 1 out of 4 patients taking NEUPRO were completely symptom-free versus placebo.

Nearly 1 out of 4 patients (23%) taking NEUPRO were completely symptom-free at the end of the study (compasred to nearly 1 out of 10 patients(9%) who used a placebo patch).

The most common side effects in people taking NEUPRO for Restless Legs Syndrome are application site reactions, nausea, difficulty falling asleep and staying asleep, sleepiness, and headache.

Why a patch may be right for you

NEUPRO is a patch that offers once-daily dosing. Simply choose the time of day that works best for you and apply the patch at the same time each day. There's no need to schedule NEUPRO around bedtime.

NEUPRO provides stable, continuous delivery 24 hours a day, so you get a consistent level of medication throughout the day.

The medication in the NEUPRO Patch does not go through your digestive system.

  • Food won't interfere with how it works
  • No pills to swallow
  • No need to schedule NEUPRO around meals
  • The medication in NEUPRO will not be affected by the digestive tract

Is RLS affecting your life?

Some people have to live their lives around their RLS symptoms. Do you?

See “How Is RLS Affecting You?” to find out >

Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away.
NEUPRO can cause nausea, vomiting, indigestion, or upset stomach, which may occur more frequently when you first start using the patch.

NEUPRO is a small, thin patch that comes in three doses: 1 mg, 2 mg, and 3 mg.

Your doctor should start you on a low dose of NEUPRO and may change the dose weekly until you are taking the right amount of medicine to control your symptoms.

Prepare for your next doctor's appointment

It's not always easy to pinpoint your feelings and communicate them to your doctor. This tool will help you get started.

Build a conversation by selecting key points from the items below. Any items you selected while using the site have already been added to your list. When you are finished, you can print or email your custom list using the buttons below.

This website does not save items added to My Doctor Conversation Builder. Be sure to print or email your list of questions before leaving this website.

Prepare for your next doctor's appointment

Build a list of key points to discuss with your doctor by selecting items from the list below. Click the "Items to ask my doctor" icon at the top of the screen to view, edit, and print your list at any time.

Assess your RLS

If you think you may have RLS, it's important to understand how much of an effect the condition has on your life. It may have a bigger impact than you realize. Below are some statements that describe how people with RLS can feel. Check the ones that apply to you. This does not take the place of a doctor visit. Only your doctor can diagnose you with RLS.

NEUPRO has been approved by the FDA to treat moderate-to-severe primary RLS and the approval was based on improvements in overall symptom scores in clinical trials. The efficacy of NEUPRO for individual symptoms has not been demonstrated. The following information is provided for your education and to help you understand your disease.

Because of my RLS:

Here's a list of common terms that people with RLS use to describe what's happening in their limbs. Do any of these describe how you're feeling? Check off the descriptions that apply to add them to My Doctor Conversation Builder.


Please select the statements that apply to you and click "submit" again.

  • Your checked items are now reflected in My Doctor Conversation Builder.

    It looks like symptoms from RLS affect you when you are trying to rest, relax, or sit still.

    NEUPRO may help.