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Myths and Realities

See how much you know

Restless Legs Syndrome (Willis-Ekbom disease) is often misunderstood and gets overlooked. Let's see how much you know about this neurological disorder called RLS. Read the five statements below and choose whether they are a reality or myth. Good luck.

1. RLS symptoms never occur during the day.

Correct. Incorrect.

Symptoms can get worse in the evening and at night. However, symptoms can be present during the day–occurring any time you're trying to rest or sit still. For some it's just occasional. But for others, it can really disrupt their lives and may require medical attention.

2. RLS is not recognized by the medical community.

Correct. Incorrect.

Decades ago, RLS was thought to be a rare condition and the medical community gave it little to no attention. However, RLS is becoming increasingly recognized as a common and important disorder – one that deserves attention, especially since up to 23 million American adults may be affected.

3. RLS symptoms affect just the legs.

Correct. Incorrect.

For some people this is true, but in many cases RLS can be felt beyond the legs. People with RLS can feel unpleasant sensations in their arms, and sometimes, in severe cases, it can spread to the torso and even the face. Learn about the basics of RLS.

4. Walking alleviates the symptoms of RLS.

Correct. Incorrect.

Physical stimulation, like walking, can temporarily relieve some of the symptoms of RLS, but the symptoms most likely will return once you stop moving. On the other hand, sitting for long periods of time, like during long car rides or at the movies, or just trying to relax, can heighten symptoms. Learn what RLS may feel like.

5. RLS is often misdiagnosed.

Correct. Incorrect.

RLS can be misdiagnosed as other conditions, such as insomnia, neuropathic pain, skin irritation, arthritis, nocturnal leg cramps, and venous disorders. There are four key criteria for a clinical diagnosis of RLS.

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NEUPRO is a prescription medicine used to treat moderate-to-severe primary Restless Legs Syndrome.


NEUPRO contains a sulfite called sodium metabisulfite. Sulfites can cause severe allergic reactions that are life threatening to some people who are sensitive to sulfites. People with asthma are more sensitive to sulfites. Remove the patch right away and call your doctor if you have swelling of the lips or tongue, chest pain, or trouble breathing or swallowing.

NEUPRO may make you fall asleep suddenly or without warning while doing normal activities, such as driving, which may result in accidents. Tell your doctor right away if this happens. Drinking alcohol or taking other medicines that cause drowsiness may increase your chances of becoming sleepy while using NEUPRO. Do not drive, use hazardous machinery, or do other dangerous activities until you know how NEUPRO affects you.

NEUPRO can cause decreases in blood pressure, especially when you start or increase your dose. Increases in blood pressure and heart rate, and fainting, also can occur. If you faint or feel dizzy, nauseated, or sweaty when you stand up from sitting or lying down, tell your doctor.

Some patients using NEUPRO get urges to behave in a way that is unusual for them, such as unusual urges to gamble, strong urges to spend money, binge eating, or increased sexual urges and behaviors. If you or your family notices you are developing any unusual behaviors, talk to your doctor.

NEUPRO may cause Restless Legs Syndrome symptoms to come back (rebound), become worse, or start earlier in the day.

Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away.

Avoid exposing the NEUPRO patch you are wearing to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, and direct sunlight. Too much medicine could be absorbed into your body. Also, do not wear NEUPRO during medical procedures called magnetic resonance imaging (MRI) or cardioversion because this could cause skin burns.

Tell your doctor if you have breathing problems, a sleep disorder, mental problems, high or low blood pressure, or heart problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. NEUPRO may not be right for you.

The most common side effects in people taking NEUPRO for Restless Legs Syndrome are application site reactions, nausea, difficulty falling asleep and staying asleep, sleepiness, and headache.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UCB, Inc. at UCBCares™ (1-844-599-2273).

Please see additional Patient Information about the NEUPRO Patch. This information does not take the place of talking with your healthcare provider about your condition or your treatment.


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