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Why NEUPRO may be right for you

Why NEUPRO may be right for you

If you have moderate-to-severe primary RLS and are experiencing uncomfortable sensations anytime you're trying to sleep, relax, or just sit still, NEUPRO® (rotigotine transdermal system) may be right for you. NEUPRO is a medication with the proven potential for RLS symptom relief. It is a patch that delivers the dopamine agonist rotigotine through the skin. With NEUPRO, your RLS symptoms are treated with one patch, once a day.


In a 6-month clinical trial, patients with moderate-to-severe primary RLS taking NEUPRO saw improvement in RLS symptoms, measured by a combined score based on the following 10 items:

  • RLS discomfort in arms and legs
  • Need to move around because of RLS symptoms
  • Relief of RLS discomfort from moving around
  • Sleep disturbance due to RLS symptoms
  • Tiredness or sleepiness during the day due to RLS symptoms
  • Severity of RLS as a whole
  • Frequency of RLS symptoms
  • Severity of RLS symptoms
  • Impact of RLS symptoms on daily activities
  • Severity of mood disturbance due to RLS symptoms

In fact, nearly 1 out of 4 patients (23%) taking NEUPRO were completely symptom-free at the end of the study (compared to nearly 1 out of 10 patients (9%) who used a placebo patch, without any medicine). In other words, these patients had a score of zero on all 10 items, which means no symptoms.

The most common side effects in people taking NEUPRO for Restless Legs Syndrome are application site reactions, nausea, difficulty falling asleep and staying asleep, sleepiness, and headache.

Why a patch may be right for you

Is RLS affecting your life?

Some people have to live their lives around their RLS symptoms. Do you?

NEUPRO is a patch that offers once-daily dosing. Simply choose the time of day that works best for you and apply the patch at the same time each day. There's no need to schedule NEUPRO around bedtime.

NEUPRO provides stable, continuous delivery 24 hours a day, so you get a consistent level of medication throughout the day.

The medication in the NEUPRO Patch does not go through your digestive system.

  • Food won't interfere with how it works
  • No pills to swallow
  • No need to schedule NEUPRO around meals
  • The medication in NEUPRO will not be affected by the digestive tract

Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away.

NEUPRO can cause nausea, vomiting, indigestion, or upset stomach, which may occur more frequently when you first start using the patch.

NEUPRO is a small, thin patch that comes in three doses: 1 mg, 2 mg, and 3 mg.

Your doctor should start you on a low dose of NEUPRO and may change the dose weekly until you are taking the right amount of medicine to control your symptoms.

Prepare for Your Next Doctor's Appointment

Build a list of key points to discuss with your doctor by selecting items from the list below. Click the "Items to ask my doctor" icon at the top of the screen to view, edit, and print your list at any time.

I'm interested to learn about how NEUPRO could help me and what I can expect from treatment.
I would like an RLS treatment like NEUPRO that delivers medicine for 24 hours.
I'm looking for a medication that I don't have to take with meals or around bedtime.
I am interested in a patch rather than a pill.
I'm already taking other medicines for other conditions and am concerned about taking another one.
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NEUPRO is a prescription medicine used to treat moderate-to-severe primary Restless Legs Syndrome.


NEUPRO contains a sulfite called sodium metabisulfite. Sulfites can cause severe allergic reactions that are life threatening to some people who are sensitive to sulfites. People with asthma are more sensitive to sulfites. Remove the patch right away and call your doctor if you have swelling of the lips or tongue, chest pain, or trouble breathing or swallowing.

NEUPRO may make you fall asleep suddenly or without warning while doing normal activities, such as driving, which may result in accidents. Tell your doctor right away if this happens. Drinking alcohol or taking other medicines that cause drowsiness may increase your chances of becoming sleepy while using NEUPRO. Do not drive, use hazardous machinery, or do other dangerous activities until you know how NEUPRO affects you.

NEUPRO can cause decreases in blood pressure, especially when you start or increase your dose. Increases in blood pressure and heart rate, and fainting, also can occur. If you faint or feel dizzy, nauseated, or sweaty when you stand up from sitting or lying down, tell your doctor.

Some patients using NEUPRO get urges to behave in a way that is unusual for them, such as unusual urges to gamble, strong urges to spend money, binge eating, or increased sexual urges and behaviors. If you or your family notices you are developing any unusual behaviors, talk to your doctor.

NEUPRO may cause Restless Legs Syndrome symptoms to come back (rebound), become worse, or start earlier in the day.

Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away.

Avoid exposing the NEUPRO patch you are wearing to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, and direct sunlight. Too much medicine could be absorbed into your body. Also, do not wear NEUPRO during medical procedures called magnetic resonance imaging (MRI) or cardioversion because this could cause skin burns.

Tell your doctor if you have breathing problems, a sleep disorder, mental problems, high or low blood pressure, or heart problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. NEUPRO may not be right for you.

The most common side effects in people taking NEUPRO for Restless Legs Syndrome are application site reactions, nausea, difficulty falling asleep and staying asleep, sleepiness, and headache.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UCB, Inc. at UCBCares™ (1-844-599-2273).

Please see additional Patient Information about the NEUPRO Patch. This information does not take the place of talking with your healthcare provider about your condition or your treatment.


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